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In contrast, the brain mostly relies on the oxidation of glucose and ketone bodies

an exceptionally high withdrawal rate was observed with once-weekly exenatide (43%), possibly related to the less comfortable pen injection device requiring resuspension of the active ingredient in buffer (Figure 3) or the occurrence of subcutaneous nodules at injection sites [175]

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Each dose increase may trigger a recurrence or intensification of side effects, even if initial symptoms had resolved