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Expert guidelines suggest that people should aim for at least 150 minutes of moderate-intensity aerobic exercise each week

Mechanistically, this complementarity is plausible: while surgery provides mechanical gastric restriction and alters gut hormone profiles, its inability to fully correct the underlying energy homeostasis dysregulation in MC4R deficiency often leads to long-term weight regain [43,45]

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However, the maximal efficacy of GLP-1R agonists alone is seemingly plateaued with increased doses, at least in diabetic patients [11]