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While some nitrosamines can cause cancer, tobacco smoke contains even higher levels, so any risks from the nitrosamines in varenicline would be outweighed by the huge health benefits of quitting smoking

Hypoxia resulting from cigarette smoking might also be responsible for impaired spermatogenesis, even more dramatically in patients with varicocele [8, 32]

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[24] The film grossed $43 million domestically and $73 million internationally, for a total of $116 million worldwide, [25] against a $4050 million production budget