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Unlike retinoids, which can cause chronic sensitivity and a plateau effect with long-term use, GHK-Cu's gene modulation data suggests ongoing regenerative signaling with sustained application

In addition, CAFs transmit information to tumor cells through the secretion of sEVs, enhancing the stemness and EMT capabilities of tumor cells, thereby promoting tumor metastasis and chemotherapy resistance [44]

In conclusion, this study indicates that oxidized glutathione (GSSG) lotion can promote skin whitening, reduce wrinkles, and improve skin moisture and smoothness 2

Moreover, a reduced protein level of GPx1 and GPx1/2 was also reported in HepG2 cells treated with palmitic and oleic acid, respectively (Chen et al

doi: 10.1111/j.1365-2133.2009.09351.x 191 PellegriniCMaturoMGMartorelliCSuppaMAntoniniAKostakiDet al