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32 Contrary to early skin model studies, Hernandez et al 32 found only low or inconsistent levels of ROS and AGEs in systemic models, suggesting that DNA damage is not primarily ROS-mediated and instead may occur through mechanisms such as glycation or crosslinking of DNA repair proteins

Prioritize protein Adequate protein intake is essential to preserve lean mass

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Such validation efforts not only strengthen the credibility of predictive models but also lay the theoretical groundwork for their clinical application