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While the copper tripeptide contains histidine (which can be oxidized to 2-oxo-histidine), this residue is already coordinated to the copper ion, and the complexs high stability constant means the copper is not freely available for catalysis

These findings are documented but derive predominantly from animal studies and should be interpreted accordingly

Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P

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Research in burn models shows GHK-Cu increases healing rates by up to 33%, partly through enhanced angiogenesis that helps burned tissue regrow blood vessels despite cauterization effects